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          產品展示
          產品名稱 丙甲菌素/阿拉霉素/Alamethicin
          產品類別 細胞培養專用試劑 >> 暫未分類
          產品簡介 Alamethicin (U-22324) is a polypeptide natural product antibiotic supplied as a mixture of homologs:
          產品定購  
           
             丙甲菌素/阿拉霉素/Alamethicin的詳細介紹:
          丙甲菌素/阿拉霉素/Alamethicin
          Biotech Grade
           
          產品規格       您的價格
           1mg           900.00
           5mg          2900.00
           10mg         5500.00
          特殊規格       請詢價
           
          說明:Alamethicin (U-22324) is a polypeptide natural product antibiotic supplied as a mixture of homologs: Alamethicin and Alamethicin I. These compounds form voltage-dependent ion channels in the lipid bilayer, through the spontaneous assembly of units into a multimeric barrel-stave structure spanning the membrane. This formation results in a hydrophilic pore which permits non-specific ion efflux through the membrane. The non-specific ion efflux obliterates the normal electrochemical gradient of the cell, producing the antibiotic property of Alamethicin. Substantiated by experiments with covalently tethered molecules of Alamethicin, It is suggested that different multimeric aggregation states create varying pore sizes with varying stabilities, correlating to differential specificity for ions. This channel-forming activity has been exploited as a tool for introducing hydrophilic small molecules into mitochondria without disrupting the integrity of the membrane.
          CAS27061-78-5
          分子式:C92H150N22O25
          分子量:1964.31
          純度:98%
          保存: 2-8℃
          From RuiTaibio
           
           
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